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The loops of the N-SH2 binding cleft do not serve as allosteric switch in SHP2 activation
The Src-homology-2 domain–containing phosphatase SHP2 is a critical regulator of signal transduction, being implicated in cell growth and differentiation. Activating mutations cause developmental disorders and act as oncogenic drivers in hematologic cancers. SHP2 is activated by phosphopeptide bindi...
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| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2021
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8092557/ https://ncbi.nlm.nih.gov/pubmed/33888588 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2025107118 |
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