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Screening and Identification of Metacaspase Inhibitors: Evaluation of Inhibition Mechanism and Trypanocidal Activity

A common strategy to identify new antiparasitic agents is the targeting of proteases, due to their essential contributions to parasite growth and development. Metacaspases (MCAs) are cysteine proteases present in fungi, protozoa, and plants. These enzymes, which are associated with crucial cellular...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Antimicrob Agents Chemother
Prif Awduron: Pérez, Brian, Bouvier, León A., Cazzulo, Juan José, Agüero, Fernán, Salas-Sarduy, Emir, Alvarez, Vanina E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2021
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092552/
https://ncbi.nlm.nih.gov/pubmed/33318019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01330-20
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