Potent and selective inhibitors for M32 metallocarboxypeptidases identified from high-throughput screening of anti-kinetoplastid chemical boxes

Enzymes of the M32 family are Zn-dependent metallocarboxypeptidases (MCPs) widely distributed among prokaryotic organisms and just a few eukaryotes including Trypanosoma brucei and Trypanosoma cruzi, the causative agents of sleeping sickness and Chagas disease, respectively. These enzymes are absent...

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Detaylı Bibliyografya
Yayımlandı:PLoS Negl Trop Dis
Asıl Yazarlar: Salas-Sarduy, Emir, Landaburu, Lionel Urán, Carmona, Adriana K., Cazzulo, Juan José, Agüero, Fernán, Alvarez, Vanina E., Niemirowicz, Gabriela T.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2019
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6675120/
https://ncbi.nlm.nih.gov/pubmed/31329594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0007560
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