Deimmunized Lysostaphin Synergizes with Small-Molecule Chemotherapies and Resensitizes Methicillin-Resistant Staphylococcus aureus to β-Lactam Antibiotics

There is an urgent need for novel agents to treat drug-resistant bacterial infections, such as multidrug-resistant Staphylococcus aureus (MRSA). Desirable properties for new antibiotics include high potency, narrow species selectivity, low propensity to elicit new resistance phenotypes, and synergy...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Fang, Yongliang, Kirsch, Jack R., Li, Liang, Brooks, Seth A., Heim, Spencer, Tan, Cynthia, Eszterhas, Susan, Cheng, Hao D., Zhao, Hongliang, Xiong, Yan Q., Griswold, Karl E.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2021
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092544/
https://ncbi.nlm.nih.gov/pubmed/33318001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01707-20
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