Transferrin receptor targeting by de novo sheet extension

The de novo design of polar protein–protein interactions is challenging because of the thermodynamic cost of stripping water away from the polar groups. Here, we describe a general approach for designing proteins which complement exposed polar backbone groups at the edge of beta sheets with geometri...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Sahtoe, Danny D., Coscia, Adrian, Mustafaoglu, Nur, Miller, Lauren M., Olal, Daniel, Vulovic, Ivan, Yu, Ta-Yi, Goreshnik, Inna, Lin, Yu-Ru, Clark, Lars, Busch, Florian, Stewart, Lance, Wysocki, Vicki H., Ingber, Donald E., Abraham, Jonathan, Baker, David
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092486/
https://ncbi.nlm.nih.gov/pubmed/33879614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2021569118
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