De novo design of picomolar SARS-CoV-2 miniprotein inhibitors

We used two approaches to design proteins with shape and chemical complementarity to the receptor binding domain (RBD) of SARS-CoV-2 Spike protein near the binding site for the human ACE2 receptor. Scaffolds were built around an ACE2 helix that interacts with the RBD, or de novo designed scaffolds w...

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Detalhes bibliográficos
Publicado no:bioRxiv
Main Authors: Cao, Longxing, Goreshnik, Inna, Coventry, Brian, Case, James Brett, Miller, Lauren, Kozodoy, Lisa, Chen, Rita E., Carter, Lauren, Walls, Lexi, Park, Young-Jun, Stewart, Lance, Diamond, Michael, Veesler, David, Baker, David
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7418719/
https://ncbi.nlm.nih.gov/pubmed/32793905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.08.03.234914
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