Chitinase 3-like 1 is a profibrogenic factor overexpressed in the aging liver and in patients with liver cirrhosis

Older age at the time of infection with hepatitis viruses is associated with an increased risk of liver fibrosis progression. We hypothesized that the pace of fibrosis progression may reflect changes in gene expression within the aging liver. We compared gene expression in liver specimens from 54 ad...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Nishimura, Norihisa, De Battista, Davide, McGivern, David R., Engle, Ronald E., Tice, Ashley, Fares-Gusmao, Rafaelle, Kabat, Juraj, Pomerenke, Anna, Nguyen, Hanh, Sato, Shinya, Bock, Kevin W., Moore, Ian N., Kleiner, David E., Zamboni, Fausto, Alter, Harvey J., Govindarajan, Sugantha, Farci, Patrizia
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2021
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092404/
https://ncbi.nlm.nih.gov/pubmed/33888584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2019633118
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