Viral expression and molecular profiling in liver tissue versus microdissected hepatocytes in hepatitis B virus - associated hepatocellular carcinoma

BACKGROUND: The molecular mechanisms whereby hepatitis B virus (HBV) induces hepatocellular carcinoma (HCC) remain elusive. We used genomic and molecular techniques to investigate host-virus interactions by studying multiple areas of the same liver from patients with HCC. METHODS: We compared the ge...

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Bibliografiske detaljer
Main Authors: Melis, Marta, Diaz, Giacomo, Kleiner, David E, Zamboni, Fausto, Kabat, Juraj, Lai, Jinping, Mogavero, Giulia, Tice, Ashley, Engle, Ronald E, Becker, Steven, Brown, Charles R, Hanson, Jeffrey C, Rodriguez-Canales, Jaime, Emmert-Buck, Michael, Govindarajan, Sugantha, Kew, Michael, Farci, Patrizia
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4142136/
https://ncbi.nlm.nih.gov/pubmed/25141867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-014-0230-1
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