The Lst Sialyltransferase of Neisseria gonorrhoeae Can Transfer Keto-Deoxyoctanoate as the Terminal Sugar of Lipooligosaccharide: a Glyco-Achilles Heel That Provides a New Strategy for Vaccines to Prevent Gonorrhea

The lipooligosaccharide (LOS) of Neisseria gonorrhoeae plays key roles in pathogenesis and is composed of multiple possible glycoforms. These glycoforms are generated by the process of phase variation and by differences in the glycosyltransferase gene content of particular strains. LOS glycoforms of...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Jen, Freda E.-C., Ketterer, Margaret R., Semchenko, Evgeny A., Day, Christopher J., Seib, Kate L., Apicella, Michael A., Jennings, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092323/
https://ncbi.nlm.nih.gov/pubmed/33758087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.03666-20
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