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The Lst Sialyltransferase of Neisseria gonorrhoeae Can Transfer Keto-Deoxyoctanoate as the Terminal Sugar of Lipooligosaccharide: a Glyco-Achilles Heel That Provides a New Strategy for Vaccines to Prevent Gonorrhea

The lipooligosaccharide (LOS) of Neisseria gonorrhoeae plays key roles in pathogenesis and is composed of multiple possible glycoforms. These glycoforms are generated by the process of phase variation and by differences in the glycosyltransferase gene content of particular strains. LOS glycoforms of...

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Vydáno v:mBio
Hlavní autoři: Jen, Freda E.-C., Ketterer, Margaret R., Semchenko, Evgeny A., Day, Christopher J., Seib, Kate L., Apicella, Michael A., Jennings, Michael P.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092323/
https://ncbi.nlm.nih.gov/pubmed/33758087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.03666-20
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