Introduction of Two Prolines and Removal of the Polybasic Cleavage Site Lead to Higher Efficacy of a Recombinant Spike-Based SARS-CoV-2 Vaccine in the Mouse Model

The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been identified as the prime target for vaccine development. The spike protein mediates both binding to host cells and membrane fusion and is also so far the only known viral target of neutralizing antibodies. Coro...

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Bibliografiske detaljer
Udgivet i:mBio
Main Authors: Amanat, Fatima, Strohmeier, Shirin, Rathnasinghe, Raveen, Schotsaert, Michael, Coughlan, Lynda, García-Sastre, Adolfo, Krammer, Florian
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2021
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Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092267/
https://ncbi.nlm.nih.gov/pubmed/33653892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02648-20
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