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Cell-Associated HIV-1 Unspliced-to-Multiply-Spliced RNA Ratio at 12 Weeks of ART Predicts Immune Reconstitution on Therapy

Incomplete restoration of CD4(+) T-cell counts on antiretroviral therapy (ART) is a major predictor of HIV-related morbidity and mortality. To understand the possible mechanisms behind this poor immunological response despite viral suppression, we longitudinally measured more than 50 virological and...

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Publicat a:mBio
Autors principals: Scherpenisse, Mirte, Kootstra, Neeltje A., Bakker, Margreet, Berkhout, Ben, Pasternak, Alexander O.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2021
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092199/
https://ncbi.nlm.nih.gov/pubmed/33688002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00099-21
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