Phenformin and ataxia‐telangiectasia mutated inhibitors synergistically co‐suppress liver cancer cell growth by damaging mitochondria

Inhibitors of ataxia–telangiectasia mutated (ATM), such as KU‐55933 (Ku), represent a promising class of novel anticancer drugs. In addition, the biguanide derivative phenformin exhibits antitumor activity superior to that of the AMPK activator metformin. Herein, we assessed the potential combinator...

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Veröffentlicht in:FEBS Open Bio
Hauptverfasser: Wu, Tianyu, Zhou, Sichun, Qin, Mei, Tang, Jing, Yan, Xinjian, Huang, Lingli, Huang, Meiyuan, Deng, Jun, Xiao, Di, Hu, Xin, Wu, Jingtao, Yang, Xiaoping, Li, Gaofeng
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2021
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8091576/
https://ncbi.nlm.nih.gov/pubmed/33742560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.13152
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