Dual Inhibition of Pirarubicin-Induced AKT and ERK Activations by Phenformin Sensitively Suppresses Bladder Cancer Growth

Activations of Akt or ERK pathway induced by clinical drugs promote therapeutic failure due to decrease of drug response, and no available strategies have been developed to solve these problems. In this study, we found that pirarubicin (THP), one important chemotherapeutic drug for treating bladder...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Peng, Mei, Deng, Jun, Zhou, Sichun, Xiao, Di, Long, Jiahui, Zhang, Nan, He, Caimei, Mo, Miao, Yang, Xiaoping
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6791928/
https://ncbi.nlm.nih.gov/pubmed/31649535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.01159
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