Rac1-PAK1 regulation of Rab11 cycling promotes junction destabilization

Rac1 GTPase is hyperactivated in tumors and contributes to malignancy. Rac1 disruption of junctions requires its effector PAK1, but the precise mechanisms are unknown. Here, we show that E-cadherin is internalized via micropinocytosis in a PAK1–dependent manner without catenin dissociation and degra...

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Udgivet i:J Cell Biol
Main Authors: Erasmus, Jennifer C., Smolarczyk, Kasia, Brezovjakova, Helena, Mohd-Naim, Noor F., Lozano, Encarnación, Matter, Karl, Braga, Vania M.M.
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8091128/
https://ncbi.nlm.nih.gov/pubmed/33914026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.202002114
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