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Rac1-PAK1 regulation of Rab11 cycling promotes junction destabilization
Rac1 GTPase is hyperactivated in tumors and contributes to malignancy. Rac1 disruption of junctions requires its effector PAK1, but the precise mechanisms are unknown. Here, we show that E-cadherin is internalized via micropinocytosis in a PAK1–dependent manner without catenin dissociation and degra...
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| Publicado no: | J Cell Biol |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Rockefeller University Press
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8091128/ https://ncbi.nlm.nih.gov/pubmed/33914026 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.202002114 |
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