Mutation of the GnRHR Proximal Promoter AP-1 Element in Mice Results in Suboptimal GnRH Induction of LH and an Abnormal Reproductive Phenotype

Reproduction is regulated by the gonadotropins, LH and FSH, which are synthesized and secreted by pituitary gonadotrophs in response to hypothalamic GnRH in a pulse frequency dependent manner. The gonadotroph decodes GnRH pulsatility via the GnRH receptor (GnRHR), which increases in expression and c...

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Veröffentlicht in:J Endocr Soc
Hauptverfasser: Hausken, Krist N, Noel, Sekoni D, Kim, Han Kyeol, Carroll, Rona Stephanie, Kaiser, Ursula B
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2021
Schlagworte:
Neuroendocrinology and Pituitary
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8090607/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvab048.1111
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