Insertion of a Synthetic Switch Into Insulin Provides Metabolite-Dependent Regulation of Hormone-Receptor Activation

Insulin signaling requires conformational change: whereas the free hormone and its receptor each adopt autoinhibited conformations, their binding leads to large-scale structural reorganization. To test the coupling between insulin’s “opening” and receptor activation, we inserted an artificial ligand...

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Veröffentlicht in:J Endocr Soc
Hauptverfasser: Chen, Yen-Shan, Gleaton, Jeremy, Yang, Yanwu, Dhayalan, Balamurugan, Phillips, Nelson B, Liu, Yule, Broadwater, Laurie, Jarosinski, Mark, Chatterjee, Deepak, Lawrence, Michael C, Hattier, Thomas, Michael, Dodson M, Weiss, Michael Aaron
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2021
Schlagworte:
Diabetes Mellitus and Glucose Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8090162/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jendso/bvab048.899
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