Insertion of a synthetic switch into insulin provides metabolite-dependent regulation of hormone–receptor activation

Insulin-signaling requires conformational change: whereas the free hormone and its receptor each adopt autoinhibited conformations, their binding leads to structural reorganization. To test the functional coupling between insulin’s “hinge opening” and receptor activation, we inserted an artificial l...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Chen, Yen-Shan, Gleaton, Jeremy, Yang, Yanwu, Dhayalan, Balamurugan, Phillips, Nelson B., Liu, Yule, Broadwater, Laurie, Jarosinski, Mark A., Chatterjee, Deepak, Lawrence, Michael C., Hattier, Thomas, Michael, M. Dodson, Weiss, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8325334/
https://ncbi.nlm.nih.gov/pubmed/34290145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2103518118
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