Lamellarin 14, a derivative of marine alkaloids, inhibits the T790M/C797S mutant epidermal growth factor receptor

The emergence of acquired resistance is a major concern associated with molecularly targeted kinase inhibitors. The C797S mutation in the epidermal growth factor receptor (EGFR) confers resistance to osimertinib, a third‐generation EGFR‐tyrosine kinase inhibitor (EGFR‐TKI). We report that the deriva...

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Publicat a:Cancer Sci
Autors principals: Nishiya, Naoyuki, Oku, Yusuke, Ishikawa, Chie, Fukuda, Tsutomu, Dan, Shingo, Mashima, Tetsuo, Ushijima, Masaru, Furukawa, Yoko, Sasaki, Yuka, Otsu, Keishi, Sakyo, Tomoko, Abe, Masanori, Yonezawa, Honami, Ishibashi, Fumito, Matsuura, Masaaki, Tomida, Akihiro, Seimiya, Hiroyuki, Yamori, Takao, Iwao, Masatomo, Uehara, Yoshimasa
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2021
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8088975/
https://ncbi.nlm.nih.gov/pubmed/33544933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.14839
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