Oncogenic KRAS–expressing organoids with biliary epithelial stem cell properties give rise to biliary tract cancer in mice

Biliary tract cancer (BTC) arises from biliary epithelial cells (BECs) and includes intrahepatic cholangiocarcinoma (IHCC), gallbladder cancer (GC), and extrahepatic cholangiocarcinoma (EHCC). Although frequent KRAS mutations and epigenetic changes at the INK4A/ARF locus have been identified, the mo...

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Detalhes bibliográficos
Publicado no:Cancer Sci
Main Authors: Kasuga, Akiyoshi, Semba, Takashi, Sato, Ryo, Nobusue, Hiroyuki, Sugihara, Eiji, Takaishi, Hiromasa, Kanai, Takanori, Saya, Hideyuki, Arima, Yoshimi
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8088913/
https://ncbi.nlm.nih.gov/pubmed/33068050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.14703
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