Exosomal proteomic signatures correlate with drug resistance and carboplatin treatment outcome in a spontaneous model of canine osteosarcoma

BACKGROUND: Osteosarcoma patients often experience poor outcomes despite chemotherapy treatment, likely due in part to various mechanisms of tumor cell innate and/or acquired drug resistance. Exosomes, microvesicles secreted by cells, have been shown to play a role in drug resistance, but a comprehe...

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Bibliografiske detaljer
Udgivet i:	Cancer Cell Int
Main Authors:	Weinman, Marcus A., Ramsey, Stephen A., Leeper, Haley J., Brady, Jacqueline V., Schlueter, Andrew, Stanisheuski, Stanislau, Maier, Claudia S., Miller, Tasha, Ruby, Carl E., Bracha, Shay
Format:	Artigo
Sprog:	Inglês
Udgivet:	BioMed Central 2021
Fag:	Primary Research
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC8088716/ https://ncbi.nlm.nih.gov/pubmed/33933069 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12935-021-01943-7
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Exosomal proteomic signatures correlate with drug resistance and carboplatin treatment outcome in a spontaneous model of canine osteosarcoma

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