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The Cell Biology of LRRK2 in Parkinson's Disease

Point mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson’s disease (PD) and are implicated in a significant proportion of apparently sporadic PD cases. Clinically, LRRK2-driven PD is indistinguishable from sporadic PD, making it an attractive genetic mo...

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Bibliographic Details
Published in:Mol Cell Biol
Main Authors: Usmani, Ahsan, Shavarebi, Farbod, Hiniker, Annie
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2021
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8088268/
https://ncbi.nlm.nih.gov/pubmed/33526455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00660-20
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