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Selective cell death in HIV-1-infected cells by DDX3 inhibitors leads to depletion of the inducible reservoir
An innovative approach to eliminate HIV-1-infected cells emerging out of latency, the major hurdle to HIV-1 cure, is to pharmacologically reactivate viral expression and concomitantly trigger intracellular pro-apoptotic pathways in order to selectively induce cell death (ICD) of infected cells, with...
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| Veröffentlicht in: | Nat Commun |
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| Hauptverfasser: | , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8087668/ https://ncbi.nlm.nih.gov/pubmed/33931637 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22608-z |
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