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Selective cell death in HIV-1-infected cells by DDX3 inhibitors leads to depletion of the inducible reservoir

An innovative approach to eliminate HIV-1-infected cells emerging out of latency, the major hurdle to HIV-1 cure, is to pharmacologically reactivate viral expression and concomitantly trigger intracellular pro-apoptotic pathways in order to selectively induce cell death (ICD) of infected cells, with...

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Bibliographische Detailangaben
Veröffentlicht in:Nat Commun
Hauptverfasser: Rao, Shringar, Lungu, Cynthia, Crespo, Raquel, Steijaert, Thijs H., Gorska, Alicja, Palstra, Robert-Jan, Prins, Henrieke A. B., van Ijcken, Wilfred, Mueller, Yvonne M., van Kampen, Jeroen J. A., Verbon, Annelies, Katsikis, Peter D., Boucher, Charles A. B., Rokx, Casper, Gruters, Rob A., Mahmoudi, Tokameh
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8087668/
https://ncbi.nlm.nih.gov/pubmed/33931637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22608-z
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