Allele-specific long-distance regulation dictates IL-32 isoform switching and mediates susceptibility to HIV-1

We integrated data obtained from HIV-1 genome-wide association studies with T cell–derived epigenome data and found that the noncoding intergenic variant rs4349147, which is statistically associated with HIV-1 acquisition, is located in a CD4(+) T cell–specific deoxyribonuclease I hypersensitive reg...

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Udgivet i:Sci Adv
Main Authors: Palstra, Robert-Jan, de Crignis, Elisa, Röling, Michael D., van Staveren, Thomas, Kan, Tsung Wai, van Ijcken, Wilfred, Mueller, Yvonne M., Katsikis, Peter D., Mahmoudi, Tokameh
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2018
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833994/
https://ncbi.nlm.nih.gov/pubmed/29507875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1701729
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