Gliotoxin, identified from a screen of fungal metabolites, disrupts 7SK snRNP, releases P-TEFb, and reverses HIV-1 latency

A leading pharmacological strategy toward HIV cure requires “shock” or activation of HIV gene expression in latently infected cells with latency reversal agents (LRAs) followed by their subsequent clearance. In a screen for novel LRAs, we used fungal secondary metabolites as a source of bioactive mo...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Stoszko, Mateusz, Al-Hatmi, Abdullah M. S., Skriba, Anton, Roling, Michael, Ne, Enrico, Crespo, Raquel, Mueller, Yvonne M., Najafzadeh, Mohammad Javad, Kang, Joyce, Ptackova, Renata, LeMasters, Elizabeth, Biswas, Pritha, Bertoldi, Alessia, Kan, Tsung Wai, de Crignis, Elisa, Sulc, Miroslav, Lebbink, Joyce H.G., Rokx, Casper, Verbon, Annelies, van Ijcken, Wilfred, Katsikis, Peter D., Palstra, Robert-Jan, Havlicek, Vladimir, de Hoog, Sybren, Mahmoudi, Tokameh
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7423394/
https://ncbi.nlm.nih.gov/pubmed/32851167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aba6617
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