Gliotoxin, identified from a screen of fungal metabolites, disrupts 7SK snRNP, releases P-TEFb, and reverses HIV-1 latency

A leading pharmacological strategy toward HIV cure requires “shock” or activation of HIV gene expression in latently infected cells with latency reversal agents (LRAs) followed by their subsequent clearance. In a screen for novel LRAs, we used fungal secondary metabolites as a source of bioactive mo...

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Vydáno v:Sci Adv
Hlavní autoři: Stoszko, Mateusz, Al-Hatmi, Abdullah M. S., Skriba, Anton, Roling, Michael, Ne, Enrico, Crespo, Raquel, Mueller, Yvonne M., Najafzadeh, Mohammad Javad, Kang, Joyce, Ptackova, Renata, LeMasters, Elizabeth, Biswas, Pritha, Bertoldi, Alessia, Kan, Tsung Wai, de Crignis, Elisa, Sulc, Miroslav, Lebbink, Joyce H.G., Rokx, Casper, Verbon, Annelies, van Ijcken, Wilfred, Katsikis, Peter D., Palstra, Robert-Jan, Havlicek, Vladimir, de Hoog, Sybren, Mahmoudi, Tokameh
Médium: Artigo
Jazyk:Inglês
Vydáno: American Association for the Advancement of Science 2020
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7423394/
https://ncbi.nlm.nih.gov/pubmed/32851167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aba6617
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