Polygenic Risk Score of Longevity Predicts Longer Survival Across an Age Continuum

Studying the genome of centenarians may give insights into the molecular mechanisms underlying extreme human longevity and the escape of age-related diseases. Here, we set out to construct polygenic risk scores (PRSs) for longevity and to investigate the functions of longevity-associated variants. U...

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Vydáno v:J Gerontol A Biol Sci Med Sci
Hlavní autoři: Tesi, Niccolo’, van der Lee, Sven J, Hulsman, Marc, Jansen, Iris E, Stringa, Najada, van Schoor, Natasja M, Scheltens, Philip, van der Flier, Wiesje M, Huisman, Martijn, Reinders, Marcel J T, Holstege, Henne
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
THE JOURNAL OF GERONTOLOGY: Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8087277/
https://ncbi.nlm.nih.gov/pubmed/33216869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glaa289
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