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Polygenic Risk Score of Longevity Predicts Longer Survival Across an Age Continuum

Studying the genome of centenarians may give insights into the molecular mechanisms underlying extreme human longevity and the escape of age-related diseases. Here, we set out to construct polygenic risk scores (PRSs) for longevity and to investigate the functions of longevity-associated variants. U...

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Detalhes bibliográficos
Publicado no:J Gerontol A Biol Sci Med Sci
Main Authors: Tesi, Niccolo’, van der Lee, Sven J, Hulsman, Marc, Jansen, Iris E, Stringa, Najada, van Schoor, Natasja M, Scheltens, Philip, van der Flier, Wiesje M, Huisman, Martijn, Reinders, Marcel J T, Holstege, Henne
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8087277/
https://ncbi.nlm.nih.gov/pubmed/33216869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glaa289
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