Centenarian controls increase variant effect sizes by an average twofold in an extreme case–extreme control analysis of Alzheimer’s disease

The detection of genetic loci associated with Alzheimer’s disease (AD) requires large numbers of cases and controls because variant effect sizes are mostly small. We hypothesized that variant effect sizes should increase when individuals who represent the extreme ends of a disease spectrum are consi...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Eur J Hum Genet
Main Authors: Tesi, Niccolò, van der Lee, Sven J., Hulsman, Marc, Jansen, Iris E., Stringa, Najada, van Schoor, Natasja, Meijers-Heijboer, Hanne, Huisman, Martijn, Scheltens, Philip, Reinders, Marcel J. T., van der Flier, Wiesje M., Holstege, Henne
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6336855/
https://ncbi.nlm.nih.gov/pubmed/30258121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41431-018-0273-5
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados