DUOX2 variants associate with preclinical disturbances in microbiota-immune homeostasis and increased inflammatory bowel disease risk

A primordial gut-epithelial innate defense response is the release of hydrogen peroxide by dual NADPH oxidase (DUOX). In inflammatory bowel disease (IBD), a condition characterized by an imbalanced gut microbiota-immune homeostasis, DUOX2 isoenzyme is the highest induced gene. Performing multiomic a...

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Pubblicato in:J Clin Invest
Autori principali: Grasberger, Helmut, Magis, Andrew T., Sheng, Elisa, Conomos, Matthew P., Zhang, Min, Garzotto, Lea S., Hou, Guoqing, Bishu, Shrinivas, Nagao-Kitamoto, Hiroko, El-Zaatari, Mohamad, Kitamoto, Sho, Kamada, Nobuhiko, Stidham, Ryan W., Akiba, Yasutada, Kaunitz, Jonathan, Haberman, Yael, Kugathasan, Subra, Denson, Lee A., Omenn, Gilbert S., Kao, John Y.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8087203/
https://ncbi.nlm.nih.gov/pubmed/33651715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI141676
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