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Detection of autoreactive CD4(+) T cells by MHC class II multimers in HLA-linked human autoimmune diseases

Recognition of self-peptides in association with distinct HLA class II alleles by autoreactive CD4(+) T cells is central for loss of immunological tolerance leading to autoimmune disease. However, identifying immunodominant self-peptides and characterizing autoreactive T cells is challenging. In thi...

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Détails bibliographiques
Publié dans:J Clin Invest
Auteurs principaux: Wieber, Karolin, Zimmer, Christine L., Hertl, Michael
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2021
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8087195/
https://ncbi.nlm.nih.gov/pubmed/33938450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI148674
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