Non-Canonical Wnt Signaling Regulates Cochlear Outgrowth and Planar Cell Polarity via Gsk3β Inhibition

During development, sensory hair cells (HCs) in the cochlea assemble a stereociliary hair bundle on their apical surface with planar polarized structure and orientation. We have recently identified a non-canonical, Wnt/G-protein/PI3K signaling pathway that promotes cochlear outgrowth and coordinates...

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Détails bibliographiques
Publié dans:Front Cell Dev Biol
Auteurs principaux: Landin Malt, Andre, Clancy, Shaylyn, Hwang, Diane, Liu, Alice, Smith, Connor, Smith, Margaret, Hatley, Maya, Clemens, Christopher, Lu, Xiaowei
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2021
Sujets:
Cell and Developmental Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8086559/
https://ncbi.nlm.nih.gov/pubmed/33937247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.649830
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