Targeting ADT-Induced Activation of the E3 Ubiquitin Ligase Siah2 to Delay the Occurrence of Castration-Resistant Prostate Cancer

Siah2 is an E3 ubiquitin ligase that targets androgen receptor (AR) and plays an important role in the development of castration-resistant prostate cancer (CRPC). However, the regulation of Siah2 in prostate cancer (PCa) is largely unknown. In this study, we used AR-dependent and -independent cells...

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Опубликовано в: :Front Oncol
Главные авторы: Yan, Tingmang, Zhou, Dapeng, Shi, Youwei, Cui, Di, Jiang, Juntao, Han, Bangmin, Xia, Shujie, Wang, Zhou, Liu, Haitao, Guo, Wenhuan, Jing, Yifeng
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2021
Предметы:
Oncology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8085430/
https://ncbi.nlm.nih.gov/pubmed/33937036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.637040
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