PRDM1 decreases sensitivity of human natural killer cells to IL2-induced cell expansion by directly repressing CD25 (IL2RA)

IL2 receptor signaling is crucial for human NK cell activation and gain of effector functions. The molecular mechanisms involved in termination of IL2 activation are largely unknown in human NK cells. PR/SET domain 1 (PRDM1) was previously reported to decrease cell growth and increase apoptosis in a...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Leukoc Biol
Prif Awduron: Akman, Burcu, Hu, Xiaozhou, Liu, Xuxiang, Hatipoğlu, Tevfik, You, Hua, Chan, Wing C., Küçük, Can
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8084872/
https://ncbi.nlm.nih.gov/pubmed/33145806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/JLB.2A0520-321RR
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