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An affinity-based, cysteine-specific ATP analog for kinase-catalyzed crosslinking

Kinases mediate cell signaling pathways by catalyzing protein phosphorylation. Irregularities in kinase activity are directly associated with disease conditions. Therefore, methods to identify substrates of a particular kinase are needed to understand signaling cascades in normal and diseased states...

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Bibliografske podrobnosti
izdano v:Angew Chem Int Ed Engl
Main Authors: Fouda, Ahmed E., Gamage, Aparni K., Pflum, Mary Kay H.
Format: Artigo
Jezik:Inglês
Izdano: 2021
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8084585/
https://ncbi.nlm.nih.gov/pubmed/33619842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202014047
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