An Fgfr3-activating mutation in immature murine osteoblasts affects the appendicular and craniofacial skeleton

Achondroplasia (ACH), the most common form of dwarfism, is caused by a missense mutation in the gene coding for fibroblast growth factor receptor 3 (FGFR3). The resulting increase in FGFR3 signaling perturbs the proliferation and differentiation of chondrocytes (CCs), alters the process of endochond...

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Bibliografiske detaljer
Udgivet i:Dis Model Mech
Main Authors: Biosse Duplan, Martin, Dambroise, Emilie, Estibals, Valentin, Veziers, Joelle, Guicheux, Jérome, Legeai-Mallet, Laurence
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists Ltd 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8084574/
https://ncbi.nlm.nih.gov/pubmed/33737326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.048272
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