Voltage-Sensing Domain of the Third Repeat of Human Skeletal Muscle NaV1.4 Channel As a New Target for Spider Gating Modifier Toxins

Voltage-gated sodium channels (NaV) have a modular architecture and contain five membrane domains. The central pore domain is responsible for ion conduction and contains a selectivity filter, while the four peripheral voltage-sensing domains (VSD-I/IV) are responsible for activation and rapid inacti...

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Veröffentlicht in:Acta Naturae
Hauptverfasser: Myshkin, M. Yu., Paramonov, A. S., Kulbatskii, D. S., Surkova, E. A., Berkut, A. A., Vassilevski, A. A., Lyukmanova, E. N., Kirpichnikov, M. P., Shenkarev, Z. O.
Format: Artigo
Sprache:Inglês
Veröffentlicht: A.I. Gordeyev 2021
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8084291/
https://ncbi.nlm.nih.gov/pubmed/33959393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.32607/actanaturae.11279
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