Cell-Free Expression of Sodium Channel Domains for Pharmacology Studies. Noncanonical Spider Toxin Binding Site in the Second Voltage-Sensing Domain of Human Na(v)1.4 Channel

Voltage-gated sodium (Na(V)) channels are essential for the normal functioning of cardiovascular, muscular, and nervous systems. These channels have modular organization; the central pore domain allows current flow and provides ion selectivity, whereas four peripherally located voltage-sensing domai...

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Vydáno v:Front Pharmacol
Hlavní autoři: Myshkin, Mikhail Yu., Männikkö, Roope, Krumkacheva, Olesya A., Kulbatskii, Dmitrii S., Chugunov, Anton O., Berkut, Antonina A., Paramonov, Alexander S., Shulepko, Mikhail A., Fedin, Matvey V., Hanna, Michael G., Kullmann, Dimitri M., Bagryanskaya, Elena G., Arseniev, Alexander S., Kirpichnikov, Mikhail P., Lyukmanova, Ekaterina N., Vassilevski, Alexander A., Shenkarev, Zakhar O.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6737007/
https://ncbi.nlm.nih.gov/pubmed/31555136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00953
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