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Discovery of a Napabucasin PROTAC as an Effective Degrader of the E3 Ligase ZFP91
Napabucasin, undergoing multiple clinical trials, was reported to inhibit the signal transducer and transcription factor 3 (STAT3). To better elucidate its mechanism of action, we designed a napabucasin-based proteolysis targeting chimera (PROTAC), XD2–149 that resulted in inhibition of STAT3 signal...
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| Pubblicato in: | J Med Chem |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8083113/ https://ncbi.nlm.nih.gov/pubmed/33506674 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c01897 |
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