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A Novel Redox Modulator Induces a GPX4-mediated Cell Death That Is Dependent on Iron and Reactive Oxygen Species
Redox modulators have been developed as an attractive approach to treat cancer. Herein, we report on the synthesis, identification and biological evaluation of a quinazolinedione reactive oxygen species (ROS) inducer, QD394, with significant cytotoxicity in pancreatic cancer cells. QD394 shows a tra...
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| Publicado no: | J Med Chem |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8082945/ https://ncbi.nlm.nih.gov/pubmed/32809827 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c01016 |
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