Rat PRDM9 shapes recombination landscapes, duration of meiosis, gametogenesis, and age of fertility

BACKGROUND: Vertebrate meiotic recombination events are concentrated in regions (hotspots) that display open chromatin marks, such as trimethylation of lysines 4 and 36 of histone 3 (H3K4me3 and H3K36me3). Mouse and human PRDM9 proteins catalyze H3K4me3 and H3K36me3 and determine hotspot positions,...

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Pubblicato in:BMC Biol
Autori principali: Mihola, Ondrej, Landa, Vladimir, Pratto, Florencia, Brick, Kevin, Kobets, Tatyana, Kusari, Fitore, Gasic, Srdjan, Smagulova, Fatima, Grey, Corinne, Flachs, Petr, Gergelits, Vaclav, Tresnak, Karel, Silhavy, Jan, Mlejnek, Petr, Camerini-Otero, R. Daniel, Pravenec, Michal, Petukhova, Galina V., Trachtulec, Zdenek
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8082845/
https://ncbi.nlm.nih.gov/pubmed/33910563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-021-01017-0
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