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CRISPR/dCas9-Mediated Parkin Inhibition Impairs Mitophagy and Aggravates Apoptosis of Rat Nucleus Pulposus Cells Under Oxidative Stress
OBJECTIVE: The aim of this study is to explore the role of Parkin in intervertebral disk degeneration (IDD) and its mitophagy regulation mechanism. STUDY DESIGN AND METHODS: Rat nucleus pulposus (NP) cells were stimulated with hydrogen peroxide (H(2)O(2)) to a mimic pathological condition. Apoptosis...
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| 出版年: | Front Mol Biosci |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Frontiers Media S.A.
2021
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8082403/ https://ncbi.nlm.nih.gov/pubmed/33937342 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2021.674632 |
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