Mitochondrial NDUFA4L2 attenuates the apoptosis of nucleus pulposus cells induced by oxidative stress via the inhibition of mitophagy

The main pathological mechanism of intervertebral disc degeneration (IVDD) is the programmed apoptosis of nucleus pulposus (NP) cells. Oxidative stress is a significant cause of IVDD. Whether mitophagy is induced by strong oxidative stress in IVDD remains to be determined. This study aimed to invest...

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Foilsithe in:Exp Mol Med
Main Authors: Xu, Wen-Ning, Zheng, Huo-Liang, Yang, Run-Ze, Liu, Tao, Yu, Wei, Zheng, Xin-Feng, Li, Bo, Jiang, Sheng-Dan, Jiang, Lei-Sheng
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2019
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6861227/
https://ncbi.nlm.nih.gov/pubmed/31740659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s12276-019-0331-2
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