Depletion of TrkB Receptors From Adult Serotonergic Neurons Increases Brain Serotonin Levels, Enhances Energy Metabolism and Impairs Learning and Memory

Neurotrophin brain-derived neurotrophic factor (BDNF) and neurotransmitter serotonin (5-HT) regulate each other and have been implicated in several neuronal mechanisms, including neuroplasticity. We have investigated the effects of BDNF on serotonergic neurons by deleting BDNF receptor TrkB from ser...

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Bibliographic Details
Published in:Front Mol Neurosci
Main Authors: Sahu, Madhusmita P., Pazos-Boubeta, Yago, Steinzeig, Anna, Kaurinkoski, Katja, Palmisano, Michela, Borowecki, Olgierd, Piepponen, Timo Petteri, Castrén, Eero
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2021
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8082189/
https://ncbi.nlm.nih.gov/pubmed/33935645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2021.616178
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