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A flexible nonlinear mixed effects model for HIV viral load rebound after treatment interruption

Characterization of HIV viral rebound after the discontinuation of antiretroviral therapy is central to HIV cure research. We propose a parametric nonlinear mixed effects model for the viral rebound trajectory, which often has a rapid rise to a peak value followed by a decrease to a viral load set p...

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Bibliografiske detaljer
Udgivet i:Stat Med
Main Authors: Wang, Rui, Bing, Ante, Wang, Cathy, Hu, Yuchen, Bosch, Ronald J., DeGruttola, Victor
Format: Artigo
Sprog:Inglês
Udgivet: 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8081565/
https://ncbi.nlm.nih.gov/pubmed/32293756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.8529
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