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A comparative analysis of the mutagenicity of platinum-containing chemotherapeutic agents reveals direct and indirect mutagenic mechanisms

Platinum-based drugs are a mainstay of cancer chemotherapy. However, their mutagenic effect can increase tumour heterogeneity, contribute to the evolution of treatment resistance and also induce secondary malignancies. We coupled whole genome sequencing with phenotypic investigations on two cell lin...

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Опубликовано в: :Mutagenesis
Главные авторы: Szikriszt, Bernadett, Póti, Ádám, Németh, Eszter, Kanu, Nnennaya, Swanton, Charles, Szüts, Dávid
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2021
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8081379/
https://ncbi.nlm.nih.gov/pubmed/33502495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/mutage/geab005
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