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A comparative analysis of the mutagenicity of platinum-containing chemotherapeutic agents reveals direct and indirect mutagenic mechanisms

Platinum-based drugs are a mainstay of cancer chemotherapy. However, their mutagenic effect can increase tumour heterogeneity, contribute to the evolution of treatment resistance and also induce secondary malignancies. We coupled whole genome sequencing with phenotypic investigations on two cell lin...

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Detalhes bibliográficos
Publicado no:Mutagenesis
Main Authors: Szikriszt, Bernadett, Póti, Ádám, Németh, Eszter, Kanu, Nnennaya, Swanton, Charles, Szüts, Dávid
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8081379/
https://ncbi.nlm.nih.gov/pubmed/33502495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/mutage/geab005
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