Validation of the 3D reconstructed human skin micronucleus (RSMN) assay: an animal-free alternative for following-up positive results from standard in vitro genotoxicity assays

In vitro test batteries have become the standard approach to determine the genotoxic potential of substances of interest across industry sectors. While useful for hazard identification, standard in vitro genotoxicity assays in 2D cell cultures have limited capability to predict in vivo outcomes and...

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Опубликовано в: :Mutagenesis
Главные авторы: Pfuhler, Stefan, Downs, Thomas R, Hewitt, Nicola J, Hoffmann, Sebastian, Mun, Greg C, Ouedraogo, Gladys, Roy, Shambhu, Curren, Rodger D, Aardema, Marilyn J
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2021
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8081377/
https://ncbi.nlm.nih.gov/pubmed/33544138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/mutage/geaa035
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