Validation of the 3D reconstructed human skin Comet assay, an animal-free alternative for following-up positive results from standard in vitro genotoxicity assays

As part of the safety assessment process, all industrial sectors employ genotoxicity test batteries, starting with well-established in vitro assays. However, these batteries have limited predictive capacity for the in vivo situation, which may result in unnecessary follow-up in vivo testing or the l...

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Dettagli Bibliografici
Pubblicato in:Mutagenesis
Autori principali: Pfuhler, Stefan, Pirow, Ralph, Downs, Thomas R, Haase, Andrea, Hewitt, Nicola, Luch, Andreas, Merkel, Marion, Petrick, Claudia, Said, André, Schäfer-Korting, Monika, Reisinger, Kerstin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2020
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Original Manuscripts
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8081376/
https://ncbi.nlm.nih.gov/pubmed/32152633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/mutage/geaa009
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