Particulate Hexavalent Chromium Inhibits E2F1 Leading to Reduced RAD51 Nuclear Foci Formation in Human Lung Cells

Lung cancer is the leading cause of cancer death; however, the mechanisms of lung carcinogens are poorly understood. Metals, including hexavalent chromium [Cr(VI)], induce chromosome instability, an early event in lung cancer. Failure of homologous recombination repair is a key mechanism for chromos...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Toxicol Sci
Main Authors: Speer, Rachel M, Toyoda, Jennifer H, Croom-Perez, Tayler J, Liu, Ke Jian, Wise, John Pierce
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2021
Teme:
Carcinogenesis
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8081024/
https://ncbi.nlm.nih.gov/pubmed/33677506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfab019
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