Tuning macrophage phenotype to mitigate skeletal muscle fibrosis: Macrophage and FAP Crosstalk in Muscular Polytrauma

Myeloid cells are critical to the development of fibrosis following muscle injury, however, the mechanism of their role in fibrosis formation remains unclear. Here we demonstrate that myeloid cell-derived TGF-β1 signaling is increased in a pro-fibrotic ischemia-reperfusion and cardiotoxin (IR/CTX) m...

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Vydáno v:J Immunol
Hlavní autoři: Stepien, David M., Hwang, Charles, Marini, Simone, Pagani, Chase A., Sorkin, Michael, Visser, Noelle D., Huber, Amanda K., Edwards, Nicole J, Loder, Shawn J, Vasquez, Kaetlin, Aguilar, Carlos, Kumar, Ravi, Mascharak, Shamik, Longaker, Michael T., Li, Jun, Levi, Benjamin
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8080967/
https://ncbi.nlm.nih.gov/pubmed/32161098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1900814
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