Pro-inflammatory interleukin-6 signaling links cognitive impairments and peripheral metabolic alterations in Alzheimer’s disease

Alzheimer’s disease (AD) is associated with memory impairment and altered peripheral metabolism. Mounting evidence indicates that abnormal signaling in a brain-periphery metabolic axis plays a role in AD pathophysiology. The activation of pro-inflammatory pathways in the brain, including the interle...

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Veröffentlicht in:Transl Psychiatry
Hauptverfasser: Lyra e Silva, Natalia M., Gonçalves, Rafaella A., Pascoal, Tharick A., Lima-Filho, Ricardo A. S., Resende, Elisa de Paula França, Vieira, Erica L. M., Teixeira, Antonio L., de Souza, Leonardo C., Peny, Julyanna A., Fortuna, Juliana T. S., Furigo, Isadora C., Hashiguchi, Debora, Miya-Coreixas, Vivian S., Clarke, Julia R., Abisambra, Jose F., Longo, Beatriz M., Donato, Jose, Fraser, Paul E., Rosa-Neto, Pedro, Caramelli, Paulo, Ferreira, Sergio T., De Felice, Fernanda G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8080782/
https://ncbi.nlm.nih.gov/pubmed/33911072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41398-021-01349-z
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