Pro-inflammatory interleukin-6 signaling links cognitive impairments and peripheral metabolic alterations in Alzheimer’s disease

Alzheimer’s disease (AD) is associated with memory impairment and altered peripheral metabolism. Mounting evidence indicates that abnormal signaling in a brain-periphery metabolic axis plays a role in AD pathophysiology. The activation of pro-inflammatory pathways in the brain, including the interle...

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Udgivet i:Transl Psychiatry
Main Authors: Lyra e Silva, Natalia M., Gonçalves, Rafaella A., Pascoal, Tharick A., Lima-Filho, Ricardo A. S., Resende, Elisa de Paula França, Vieira, Erica L. M., Teixeira, Antonio L., de Souza, Leonardo C., Peny, Julyanna A., Fortuna, Juliana T. S., Furigo, Isadora C., Hashiguchi, Debora, Miya-Coreixas, Vivian S., Clarke, Julia R., Abisambra, Jose F., Longo, Beatriz M., Donato, Jose, Fraser, Paul E., Rosa-Neto, Pedro, Caramelli, Paulo, Ferreira, Sergio T., De Felice, Fernanda G.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8080782/
https://ncbi.nlm.nih.gov/pubmed/33911072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41398-021-01349-z
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